Reliability in research matters.

One of the things I have just done is out myself, by linking explicitly to my university profile. The fact I blog as a reformed tory is no great secret. But it means that I can talk a little more about the science part of the title.

Ingvild M Tollefsen, Erlend Hem and Oivind Ekeberg have just systematically reviewed all studies on the reliability of suicide statistics. This is not a trivial question. One of the outcomes that clinicians try to avoid when dealing with those who are mad or in despair is suicide. The rate is much higher in psychiatric patients than the general population. There is a entire literature on the variability of suicude rates by country and over time.

What these authors, claim however, is that the official statistics are unreliable, and tend to under report.

SUmmary table from BMC Psychiatry

One of the basic issues in epidemiology is reliability. Your statistics may not be valid — I’d argue, for instance, that the US race classification is not valid — but they need to be reliable. You can’t have validity without reliability. It looks like the human bias to call suicide anything but (and avoid the shame of this event) is hiding the problem from populations, and not allowing researchers to be certain about anything. Clear, reliable data helps generate hypotheses, whcih can then be tested and out of the detritus of failed explanations we winnow out truth.

But without reliability, the scientific method does not have much power. We are all running blind. We cannot suggest ways to improve what we measure poorly. This paper confronts us all: the institutionalised practice of silence hurts the living, because we cannot learn from the tragedies of the past.

Reliability of measures matters. Methodology matters. And anyone who claims to be working in the social sciences and tells you otherwise is a fool or a liar.

Biology of rat ?psychosis.

 

Schematic representation of the effects exerted by PS on the dopaminergic function. The data correspond to the VTA–PFC pathway of an offspring that was prenatally stressed employing a restraint protocol. The effects described occur at different stages of development. PS exerts an inhibitory effect (indicate by [?

This is taken from a paper reviewing the research into dopamine pathways using the offspring of rat mothers who are stressed while pregnant. The link to Pubmed is here: the paper is behind a paywall.

You may say this is rats — but mothers who bear children during famines have an increased rate of psychosis (Pubmed)

There is also a bit of clinical lore. People who have methamphetamine induced psychosis can be vulnerable to a second relapse when they have very little methamphetamine (the same applies for other stimulants).  If you have recurrent events… you only need to be stressed.

The trouble is by then certain people are already in trouble. Their previous growth and development — even in the womb — has made them vulnerable. We may not be rats, but we can learn about the mechanisms of this from them.

 

Tests of the Antichrist.

No clever comments this morning, for this passage is serious.

1 John 2:18-29

18Children, it is the last hour! As you have heard that antichrist is coming, so now many antichrists have come. From this we know that it is the last hour. 19They went out from us, but they did not belong to us; for if they had belonged to us, they would have remained with us. But by going out they made it plain that none of them belongs to us. 20But you have been anointed by the Holy One, and all of you have knowledge. 21I write to you, not because you do not know the truth, but because you know it, and you know that no lie comes from the truth. 22Who is the liar but the one who denies that Jesus is the Christ? This is the antichrist, the one who denies the Father and the Son. 23No one who denies the Son has the Father; everyone who confesses the Son has the Father also. 24Let what you heard from the beginning abide in you. If what you heard from the beginning abides in you, then you will abide in the Son and in the Father. 25And this is what he has promised us, eternal life.

26I write these things to you concerning those who would deceive you. 27As for you, the anointing that you received from him abides in you, and so you do not need anyone to teach you. But as his anointing teaches you about all things, and is true and is not a lie, and just as it has taught you, abide in him. 28And now, little children, abide in him, so that when he is revealed we may have confidence and not be put to shame before him at his coming.29If you know that he is righteous, you may be sure that everyone who does right has been born of him.

Now, we have the ability to choose. God knows us, and intervenes, because by nature we would choose the evil and perverse sufficiently to corrupt ourselves. Within the Church there are those who are against the church. Some have declared themselves and left: they at least have a remnant of honesty. Others are there poisoning the conversations and corrupting the holy.

So what are the signs.

  1. They have become apostate.
  2. They deny that Jesus is the Christ. That is why the liberal church is dying — it is anti-christian and the spirit will not remain with the anti-christian. To those who are within a liberal congregation the text is always the same: Flee Babylon.  Find a congregation where the word is preached.
  3. There is no denominational brand that prevents this. It can happen to the Catholics. It can happen among the Reformed. It happens frequently among the followers of Arminius (Methodists) and the Pentecostals. The sheep need to watch the shepherds and test their words.
  4. Our job is to remain in Christ. There is no new teaching. There is but Christ.

We need to pray for the leaders of our churches as they are gathered — from Ratzinger to whoever is the moderator of the Presbyterian assembly this year. They have to not only guide the rest of us, but weed out these blots, these thorns, these corrupters. It is one of the reasons the office of the inquisition existed within the Catholic Church.

For the Church is Christ’s and if we can confront a person who is anti-Christian with Christ so that he repents, heaven itself  rejoices.