What I’ve done is changed the advice on the contact page to my gmail account: I can get at the spam there. Try pukeko60 [at] gmail.com: that should work.

As for the research area, it’s not too surprising that the adjunctive treatments help. The Brain is the largest user of Energy in the body, so addressing core system problems always frees up the body to handle the main problem it has. Assuming the problem hasn’t reached beyond the body’s capacity for self-repair. If it’s at that point, that gets a lot more complicated.

Granted, the real problem if figuring out what core systems are effected by the mental disorder, which changes what needs to be done for the patient. There’s never a “one-size fits all” solution, a problem that’s plagued medicine for so very long.

On your point, let’s say that the antipodean psychiatrists have looked at antioxidants such as fish oil or N-acetyl cystiene, or even nitroprusside to augment treatment. The current theory is that cortisol triggers glia to destroy synapses, and this synatic destruction is not that genetically driven. (current models have Schizophrenia as 30% genetic. Diabetes has a higher weighting)..You need to stop this process and allow synaptic repair, which requires BDNF, and it appears that most powerful antioxidants can do this.

My local team have some ideas, but one talks of results, not hypotheses. All the compounds above have at least open label trials showing that they work.

Technical posts are rare here simply because I generally don’t do work on the blog

Once the body is into a low-level version of nervous system shock, the body will leech desperately from whatever low-return source responds to the signalling, in a vain attempt to establish a functional homeostasis. We don’t have much issue understanding that the body will do this if its protein deficient, working through muscle and into organs (and thus permanent organ damage), but the instant the Brain is involved, it feels like most doctors & researchers start deactivating theirs. Yes, it’s highly complex in the functional details, but the basic systematic aspects are still the same. Mostly as without electro-chemical homeostasis in nerves, they blow up very quickly and you’re very dead.

In this instance, though, it’d take some very deep study of the cell-receptor changes along the cardio-vascular system. Given the likely desired candidates that the nervous system would be after (phospholipids) are most easily scavenged from the vascular track, that would be a very good place to start looking. But that requires cadaver study and it’d require some pretty slick work to pull off an animal model. Though I imagine it’s possible.

I’m going to guess this is the most technical comment you’ve ever gotten, but I’m curious if you got my e-mail.