Genetics of depression show sexual dimorphism?
The genetics of depression has been an interestly difficult problem. In this paper, which is long, complex, and well worth reading, post mortem brain samples are used to demonstrate differential genetic expression by region between people with depression and controls, that differ by sex. This is then replicated in mice experimental models, and using a […] Read More
Watch this neuroimaging space?
Some of the tools we have coming out of the Magnetic Resonance Suite look attractive, such as high resolution diffusion imaging. On a population basis, you can see the difference between normal, psychotic, depressed and manic networks. The pictures are pretty, and some of them may be useful. Recent work from the international Study to […] Read More
What antidepressant matters.
When you do acute, crisis, community or inpatient psychiatry, you are using medications that in overdose can be risky. Moreover, you are working with people who have a tendency to overdose. So what you prescribe and how you prescribe matters. This paper, in the American Journal of Psychiatry has two important findings. The first is […] Read More
Your cellphone as a ‘therapist’.
I have been aware of the use of internet based CBT, including the development of cellphone apps, for about a decade. We are now at the meta analysis stage of evaluating this technology. I would suggest any interested people read the paper, as it is freely available. As a clinician, the attractive thing about iCBT […] Read More
Which outcome you report matters.
This is an example of how you can play with data to get a positive result: and also that with major amounts of money in a study you better get a positive result. It comes from a large multicentre trial of a novel antidepressant compound that modifies glutamate, basimglurant. The authors used a standard depression […] Read More